Side Effects
Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, headache, or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you are taking tramadol regularly, it may be useful to start using a laxative right away instead of waiting until you become constipated. Consult your pharmacist for details regarding the correct use of laxatives (e.g., stimulant-type with stool softener).
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual or extreme stiffness in the muscles, shaking (tremor), severe stomach/abdominal pain, change in the amount of urine, vision changes.
This medication may rarely cause a very serious condition called serotonin syndrome. The risk increases when this medication is used with certain other drugs (see Drug Interactions section). Seek immediate medical attention if you develop some of the following symptoms: mental/mood changes (such as agitation, hallucinations), unusual restlessness, loss of coordination, fast heartbeat, severe dizziness, unexplained fever, severe nausea/vomiting/diarrhea, twitchy muscles.
Tell your doctor immediately if any of these rare but very serious side effects occur: slow/shallow breathing, seizures, fever/flu-like symptoms.
A very serious allergic reaction to this drug (which may occur as early as the first dose) is rare. However, seek immediate medical attention if you notice any of the following symptoms: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
The following side effects are associated with Tramadol Oral:
Infrequent side effects:
| Blurred Vision | Severe |
| Cannot Empty Bladder | Severe |
| Frequent Urination | Severe |
| Extreme Sense of Well Being | Less Severe |
| Widening of Blood Vessels | Less Severe |
| Dry Mouth | Less Severe |
| Indigestion | Less Severe |
| Incomplete or Infrequent Bowel Movements | Less Severe |
| “Change of Life” Signs | Less Severe |
| Drowsiness | Less Severe |
| Dizzy | Less Severe |
| Chronic Trouble Sleeping | Less Severe |
| Excessive Sweating | Less Severe |
| Voluntary Movement Difficulty | Less Severe |
| Rash | Less Severe |
| Loss of Appetite | Less Severe |
| Head Pain | Less Severe |
| Feel Like Throwing Up | Less Severe |
| Throwing Up | Less Severe |
| Gas | Less Severe |
| Diarrhea | Less Severe |
| Stomach Cramps | Less Severe |
| Nervous | Less Severe |
| Feeling Weak | Less Severe |
| Confused | Less Severe |
| Over Excitement | Less Severe |
| Anxious | Less Severe |
Rare side effects:
| Serotonin Syndrome – Adverse Drug Interaction | Severe |
| Blood Pressure Drop Upon Standing | Severe |
| Bronchospasm | Severe |
| Toxic Epidermal Necrolysis | Severe |
| Stevens-Johnson Syndrome | Severe |
| Redness of Skin | Severe |
| Itching | Severe |
| Hives | Severe |
| Small Skin Blister | Severe |
| Loss of Memory | Severe |
| Hallucination | Severe |
| Feeling Faint | Severe |
| Seizures | Severe |
| Involuntary Quivering | Severe |
| Fast Heartbeat | Severe |
| Trouble Breathing | Severe |
| Life Threatening Allergic Reaction | Severe |
| Giant Hives | Severe |
| Reaction due to an Allergy | Severe |
| Numbness and Tingling | Severe |
| Taking Habit Forming Drugs | Less Severe |
| Feeling Restless | Less Severe |
| Depression | Less Severe |
| Migraine Headache | Less Severe |
| Problems with Eyesight | Less Severe |
| Decreased Pupil Size | Less Severe |
| Ringing in the Ears | Less Severe |
| High Blood Pressure | Less Severe |
| Abnormal Increase in Muscle Tone | Less Severe |
| Abnormal Manner of Walking | Less Severe |
| Weight Loss | Less Severe |
| Heart Throbbing or Pounding | Less Severe |
| Difficult or Painful Urination | Less Severe |
